Sakurako Kintoki

Sedusa can drastically alter her appearance by adding or removing makeup and is a master of disguise, which Sedusa was known for in the original Powerpuff Girls alongside her seductive manner. She takes the form of many people in order to get into stores and steal from them, including Bubbles and Buttercup. Sedusa is the alter-ego of the girls' friend, Sakurako. Sakurako works at a shop, well-known around the area for her desserts (Momoko, Miyako, Kaoru, Himeko, and Miss Bellum often visit the shop because of this). When working at her shop, she wanted to be sexy after seeing Miss Bellum.

Sakurako has a crush on Souichirou, a boy who comes to her shop often; this was her primary reason for wanting to be sexy like Miss Bellum. In order to become Sedusa, Sakurako must use lipstick. With a little makeup, she can take on the appearance of anyone, although anything like the scent of perfume won't be masked. She, with her looks, is also able to coax many nearby males into doing what she wants (although it comes off more naturally than the original, since the original Sedusa had to disguise herself). She is also able to perform the original Sedusa's signature hair whip/tentacle attacks.

She was defeated and later transformed back into Sakurako through the use of Professor Utonium's Chemical Z Particle Ray. Sakurako was able to win Souichirou's heart at the end of episode 8, although the two are still shy to each other. Sakurako later appears in episode 25, receiving flowers from Souichirou and she also soothes Here, a flower who fell victim to the black powder. Like Himeko/Princess, Sakurako can still transform into Sedusa at any time as long as lipstick is applied on Sakurako. It was revealed in episode 28 that the lipstick doesn't even need to be applied directly to her lips; she will still transform into Sedusa if it's smeared on her face.