Юкішіро Еніші

When Enishi was an infant, his mother died and he was raised by his older sister, Tomoe. She raised him herself, becoming both sister and mother to him, and he grew to love her quite dearly. When Tomoe became engaged to Kiyosato Akira, Enishi reluctantly accepted him because Kiyosato truly made Tomoe happy and she loved him. Kiyosato later joined the Mimawarigumi believing that the sombre Tomoe would be happy if he became a hero, only to be killed by Hitokiri Battōsai (Himura Kenshin) for the new era. Tomoe left her brother behind to seek revenge, working with spies from the Shogunate to do so. Enishi became consumed by his loneliness to bring her back to Edo (now Tokyo) so they could be together.

When he was about ten, Enishi ran away from Edo, disappearing for seven months. He discovered the location of Tomoe through the Shogun agency and soon appeared before her, revealing that he was the Shogun agency's contact sent to Tomoe. While he believed that he was helping Tomoe's revenge, he did not know Tomoe had grown to love Kenshin, despite the fact he killed Kiyosato. She sent him away, hoping to protect Kenshin, leaving her brother angry and confused by her actions. After witnessing Kenshin's accidental killing of Tomoe, his hair turned snow white from the stress and grief of losing her.

Enishi became more unstable and swore Jinchū (Man's Punishment) to be brought down on Kenshin's head for destroying his sister's happiness and then killing her. He disappeared to China, where he is taken in by a kind and wealthy family after suffering months of hardship in the wilderness. He later killed them all and took their money, unable to bear seeing how happy they were.